Spayvac uses pZP, GnRH, or other antigens to trigger An immune response
SpayVac vaccines harness the animal's own immune system to prevent pregnancy. For horses, deer, and several other species, the vaccine uses porcine Zona Pellucida (pZP) as the active ingredient. Zona Pellucida is a mesh-like membrane that surrounds the egg and is the binding site for sperm. Females vaccinated with pZP produce antibodies that bind to their ZP and block fertilization.
Depending on the species and application, SpayVac vaccines use different antigens, such as Gonadotropin-Releasing Hormone (GnRH), to achieve safe and effective long-term contraception.
Proprietary liposome-based formulation
Our proprietary phospholipid-based formulation is composed of naturally occurring fatty particles called liposomes. Liposomes encapsulate the antigen, efficiently training the immune system, which results in a superior, long-lasting immune response.
How it works
SpayVac is administered as a single intramuscular injection, which stimulates the immune system to create antibodies targeting a particular part of the reproductive system. Decades of research with SpayVac and other pZP- and GnRH-based vaccines have demonstrated the safety of these vaccines. SpayVac has no effect on pregnant animals or on the developing fetus. Because females contracepted for multiple years do not experience pregnancies and the energy demands of lactation, they generally have improved body condition and extended lifespans. Ultimately, the vaccine components break down within the animal and do not accumulate in the animal or pass through the food chain.