SPAYVAC DESCRIPTION

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SpayVac is a single-dose (or no-booster-needed) fertility-control vaccine that uses pZP or other antigens as the active ingredient.

Zona Pellucida (ZP) is a translucent, mesh-like membrane.  The ZP surrounds the egg and is the binding site for sperm. Females vaccinated with pZP produce antibodies that bind to their ZP and block fertilization. Other antigens, besides pZP, can be used in SpayVac for different species.

Vaccimax is composed of fatty particles called liposomes. Liposomes encapsulate the pZP, creating a superior long-lasting immune response.

A liposome is a small sphere, made out of the same material as a cell membrane. Liposomes can be used to deliver antigens for vaccines. There are many advantages of liposomes. The biggest advantage is the cell membrane and the liposome membrane consist of the same phospholipid bilayer. This biocompatibility helps the immune system process the antigen, for example, pZP in the case of SpayVac.

SpayVac is injected into the female. The immune system then creates proteins in response. These proteins are called antibodies. When we use pZP as the antigen,  the antibodies block sperm from binding to the egg’s zona pellucida membrane. This immune response creates the long-term fertility control effect.

• Feral horses (three completed trials)
• Deer (four completed trials in three species of deer)
• Macaques (one completed trial)
• Seals (one completed trial)
• Elephants (one completed trial)