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FAQs

Can I buy SpayVac?

SpayVac is not yet approved for sale. It can be purchased for research studies with an Experimental Use Permit. Please contact us if you are interested in exploring research opportunities.

ABOUT PZP

What is SpayVac?

SpayVac is an immunocontraceptive vaccine that uses the pZP antigen in a patented liposomal delivery system to create an immune response. The immune system of the inoculated animal will produce antibodies to ZP. These antibodies competitively bind to the ZP surface matrix thus blocking sperm from being able to bind and therefore preventing fertilization. (pictured right: ZP or zona pelucida matrix covering an mammalian egg)

What is SpayVac?

SpayVac is an immunocontraceptive vaccine that uses the pZP antigen in a patented liposomal delivery system to create an immune response. The immune system of the inoculated animal will produce antibodies to ZP. These antibodies competitively bind to the ZP surface matrix thus blocking sperm from being able to bind and therefore preventing fertilization. (pictured right: ZP or zona pelucida matrix covering an mammalian egg)

What does pZP mean and what is it?

pZP means porcine zona pellucida.
Zona pellucida is a glycoprotein which is found wrapped around mammalian eggs. One of these glycoproteins, ZP3, is a critical receptor protein for sperm and therefore key to the fertilzation of the egg. The pZP vaccine is derived from porcine (or pig ovaries) and therefore, when referring to the antigen used in the vaccine, it is called pZP.

MORE ON SPAYVAC

How Does SpayVac Work?

When the SpayVac vaccine is injected into the female , it stimulates the immune system to produce antibodies against the ZP protein. These antibodies will attach to the ZP layer around the outside of the egg where there are sperm receptors. These antibodies occupy all the receptor sites blocking sperm from fertilizing the egg.

Has SpayVac been tested?

There have been multiple studies demonstrating efficacy in several overabundant wildlife populations such as wild horses, deer, macaques, seals, and elephants. There are pending trials in farm-raised trout and bears. In each completed study, a single dose of SpayVac has demonstrated long-acting contraception. To see the list of publications follow this link to the More About SpayVac page

Is SpayVac approved?

SpayVac is not yet approvedfor sale. It can be purchased for field trials with an Experimental Use Permit as part if a research project prior to approval. Please contact us for more details if you are interested. We are experienced in running trials and can help obtain the necessary permits for testing.

Can I buy SpayVac?

SpayVac is not yet approved for sale. It can be purchased for research studies with an Experimental Use Permit. Please contact us if you are interested in exploring research opportunities.

Market Forces Demand Game-Changing Fertility Control

Wild and feral animals

STAGE 1: Wild Animals.

  • Feral horses in USA, Australia and Danube River Delta in Europe-- billions spent managing over population.
  • Feral burros are a global challenge with an estimated 10 million feral animals globally on six continents.
  • Deer overpopulation in urban areas cause billions of dollars in property damage, spread tick-borne diseases and billions of dollars in vehicle collisions. Hundreds of millions of dollars are spent annually on deer remidiation.

Aquaculture and Agricultural production animals

STAGE 2: Aquaculture And Production Animals In Agriculture.

  • Farm-raised fish that spawn and produce eggs gain less weight. Preventing fertilization has a direct economic benefit.
  • Environmental concerns about escaped farm-raised fish mixing with wild-type fish and altering the gene pool is a growing concern. Fertility control will mitigate against that risk.

Companion animals

STAGE 3: Pets , Companion Animals

  • The primary fertility control method used around the world for cats and dogs is surgery. There are parts of the world where surgery may not be used at all or there are low rates of surgery. As part of our Stage-1 development , we will begin development of fertility-control vaccine for the one-billion feral cats and feral dogs around the world. From the dosing, safety and efficacy data we gather in feral dogs and cats, we will transition to companion animals and run pivotal trials.

SPAYVAC

Creating humane fertility control vaccines for animals
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